The Medical Issue

Coronary Artery Disease (“CAD”)

  • The leading cause of premature death worldwide, accounting for more deaths than all cancers combined.
  • Predicted to increase 18% by 2030 due to patient obesity, stress due to lifestyle factors, and aging populations1.

Detection is a substantial challenge:

  • Only 20% of CAD cases are diagnosed prior to a heart attack2.
  • In 57% of cases, sudden cardiac death is the first symptom3.

Lifetime risk of developing CAD after age 401


The % of Sudden Cardiac Deaths where patients were previously asymptomatic


The Challenge

Diagnostic Accuracy of Exercise Stress Test


Current Diagnostics Have Limitations and Risks

  • Coronary Computed Tomography Angiography (CCTA) and Invasive Coronary Angiography (ICA) have high diagnostic accuracy, but are cost prohibitive for widespread use, and expose patients to the equivalent of between 3.8 and 7.7 years of background radiation.
  • First line diagnostics such as exercise treadmill test are lower cost, but lack sufficient diagnostic accuracy, resulting in unnecessary referrals to CCTA and ICA.
  • Between 25% and 50% of patients receiving CCTA and ICA procedures have no obstructive CAD

Lack of an accurate, cost-effective, and patient-friendly modality for CAD detection has resulted in:

  • High costs for payors.
  • Diagnostic challenges for physicians.
  • Adverse outcomes and inconvenience for patients.
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