The 
System
AusculSciences, Inc., a medical technology research and development company, is dedicated to advancing tools that support healthcare professionals in cardiovascular assessment. Current efforts focus on the CAD-det System, a noninvasive cardiovascular assessment support device intended for use on adult patients undergoing clinical evaluation for suspected cardiovascular disease.
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The Medical Issue
Coronary Artery Disease (“CAD”)
- The leading cause of premature death worldwide, accounting for more deaths than all cancers combined.
- Predicted to increase 18% by 2030 due to patient obesity, stress due to lifestyle factors, and aging populations1.
Detection is a substantial challenge:
- Only 20% of CAD cases are diagnosed prior to a heart attack2.
- In 57% of cases, sudden cardiac death is the first symptom3.
Lifetime risk of developing CAD after age 401
48%
Men
32%
Women
The % of Sudden Cardiac Deaths where patients were previously asymptomatic
50%
Men
64%
Women
The Challenge
Diagnostic Accuracy of Exercise Stress Test
67%
Sensitivity
46%
Specificity
Current Diagnostics Have Limitations and Risks
- Coronary Computed Tomography Angiography (CCTA) and Invasive Coronary Angiography (ICA) have high diagnostic accuracy, but are cost prohibitive for widespread use, and expose patients to the equivalent of between 3.8 and 7.7 years of background radiation.
- First line diagnostics such as exercise treadmill test are lower cost, but lack sufficient diagnostic accuracy, resulting in unnecessary referrals to CCTA and ICA.
- Between 25% and 50% of patients receiving CCTA and ICA procedures have no obstructive CAD
Lack of an accurate, cost-effective, and patient-friendly modality for CAD detection has resulted in:
- High costs for payors.
- Diagnostic challenges for physicians.
- Adverse outcomes and inconvenience for patients.